diff --git a/server/src/main/java/com/genymobile/scrcpy/Controller.java b/server/src/main/java/com/genymobile/scrcpy/Controller.java
index bff01d9f..b0b0c787 100644
--- a/server/src/main/java/com/genymobile/scrcpy/Controller.java
+++ b/server/src/main/java/com/genymobile/scrcpy/Controller.java
@@ -1,5 +1,7 @@
 package com.genymobile.scrcpy;
 
+import com.genymobile.scrcpy.wrappers.InputManager;
+
 import android.os.Build;
 import android.os.SystemClock;
 import android.view.InputDevice;
@@ -99,7 +101,7 @@ public class Controller {
                 break;
             case ControlMessage.TYPE_INJECT_TOUCH_EVENT:
                 if (device.supportsInputEvents()) {
-                    injectTouch(msg.getAction(), msg.getPointerId(), msg.getPosition(), msg.getPressure(), msg.getButtons());
+                    injectTouch(msg.getAction(), msg.getPointerId(), msg.getPosition(), msg.getPressure(), msg.getActionButton(), msg.getButtons());
                 }
                 break;
             case ControlMessage.TYPE_INJECT_SCROLL_EVENT:
@@ -179,7 +181,7 @@ public class Controller {
         return successCount;
     }
 
-    private boolean injectTouch(int action, long pointerId, Position position, float pressure, int buttons) {
+    private boolean injectTouch(int action, long pointerId, Position position, float pressure, int actionButton, int buttons) {
         long now = SystemClock.uptimeMillis();
 
         Point point = device.getPhysicalPoint(position);
@@ -226,6 +228,62 @@ public class Controller {
             }
         }
 
+        /* If the input device is a mouse (on API >= 23):
+         *   - the first button pressed must first generate ACTION_DOWN;
+         *   - all button pressed (including the first one) must generate ACTION_BUTTON_PRESS;
+         *   - all button released (including the last one) must generate ACTION_BUTTON_RELEASE;
+         *   - the last button released must in addition generate ACTION_UP.
+         *
+         * Otherwise, Chrome does not work properly: <https://github.com/Genymobile/scrcpy/issues/3635>
+         */
+        if (Build.VERSION.SDK_INT >= Build.VERSION_CODES.M && source == InputDevice.SOURCE_MOUSE) {
+            if (action == MotionEvent.ACTION_DOWN) {
+                if (actionButton == buttons) {
+                    // First button pressed: ACTION_DOWN
+                    MotionEvent downEvent = MotionEvent.obtain(lastTouchDown, now, MotionEvent.ACTION_DOWN, pointerCount, pointerProperties,
+                            pointerCoords, 0, buttons, 1f, 1f, DEFAULT_DEVICE_ID, 0, source, 0);
+                    if (!device.injectEvent(downEvent, Device.INJECT_MODE_ASYNC)) {
+                        return false;
+                    }
+                }
+
+                // Any button pressed: ACTION_BUTTON_PRESS
+                MotionEvent pressEvent = MotionEvent.obtain(lastTouchDown, now, MotionEvent.ACTION_BUTTON_PRESS, pointerCount, pointerProperties,
+                        pointerCoords, 0, buttons, 1f, 1f, DEFAULT_DEVICE_ID, 0, source, 0);
+                if (!InputManager.setActionButton(pressEvent, actionButton)) {
+                    return false;
+                }
+                if (!device.injectEvent(pressEvent, Device.INJECT_MODE_ASYNC)) {
+                    return false;
+                }
+
+                return true;
+            }
+
+            if (action == MotionEvent.ACTION_UP) {
+                // Any button released: ACTION_BUTTON_RELEASE
+                MotionEvent releaseEvent = MotionEvent.obtain(lastTouchDown, now, MotionEvent.ACTION_BUTTON_RELEASE, pointerCount, pointerProperties,
+                        pointerCoords, 0, buttons, 1f, 1f, DEFAULT_DEVICE_ID, 0, source, 0);
+                if (!InputManager.setActionButton(releaseEvent, actionButton)) {
+                    return false;
+                }
+                if (!device.injectEvent(releaseEvent, Device.INJECT_MODE_ASYNC)) {
+                    return false;
+                }
+
+                if (buttons == 0) {
+                    // Last button released: ACTION_UP
+                    MotionEvent upEvent = MotionEvent.obtain(lastTouchDown, now, MotionEvent.ACTION_UP, pointerCount, pointerProperties,
+                            pointerCoords, 0, buttons, 1f, 1f, DEFAULT_DEVICE_ID, 0, source, 0);
+                    if (!device.injectEvent(upEvent, Device.INJECT_MODE_ASYNC)) {
+                        return false;
+                    }
+                }
+
+                return true;
+            }
+        }
+
         MotionEvent event = MotionEvent
                 .obtain(lastTouchDown, now, action, pointerCount, pointerProperties, pointerCoords, 0, buttons, 1f, 1f, DEFAULT_DEVICE_ID, 0, source,
                         0);
diff --git a/server/src/main/java/com/genymobile/scrcpy/wrappers/InputManager.java b/server/src/main/java/com/genymobile/scrcpy/wrappers/InputManager.java
index 38e96d45..32bf4252 100644
--- a/server/src/main/java/com/genymobile/scrcpy/wrappers/InputManager.java
+++ b/server/src/main/java/com/genymobile/scrcpy/wrappers/InputManager.java
@@ -3,6 +3,7 @@ package com.genymobile.scrcpy.wrappers;
 import com.genymobile.scrcpy.Ln;
 
 import android.view.InputEvent;
+import android.view.MotionEvent;
 
 import java.lang.reflect.InvocationTargetException;
 import java.lang.reflect.Method;
@@ -17,6 +18,7 @@ public final class InputManager {
     private Method injectInputEventMethod;
 
     private static Method setDisplayIdMethod;
+    private static Method setActionButtonMethod;
 
     public InputManager(android.hardware.input.InputManager manager) {
         this.manager = manager;
@@ -56,4 +58,22 @@ public final class InputManager {
             return false;
         }
     }
+
+    private static Method getSetActionButtonMethod() throws NoSuchMethodException {
+        if (setActionButtonMethod == null) {
+            setActionButtonMethod = MotionEvent.class.getMethod("setActionButton", int.class);
+        }
+        return setActionButtonMethod;
+    }
+
+    public static boolean setActionButton(MotionEvent motionEvent, int actionButton) {
+        try {
+            Method method = getSetActionButtonMethod();
+            method.invoke(motionEvent, actionButton);
+            return true;
+        } catch (InvocationTargetException | IllegalAccessException | NoSuchMethodException e) {
+            Ln.e("Cannot set action button on MotionEvent", e);
+            return false;
+        }
+    }
 }